On October 25 & 26, 1942, less than two weeks after landing on Guadalcanal, the 164th infantry Regiment would become involved in the heaviest fighting of the Guadalcanal Campaign after the Japanese launched a surprise offensive.
The 164th Infantry Regiment held key sectors around Henderson Field and repelled the attacking Japanese forces. Members of the 164th killed over 1,500 of the attacking Japanese forces while suffering 26 KIA's and 52 wounded.